Article Text

PDF
CASE REPORT
Ninety-year-old man with hypereosinophilia, lymphadenopathies and pruritus
  1. José Guilherme Freitas1,
  2. Ana Jorge2,
  3. Daniel Rei3,
  4. Joana Graça4
  1. 1Department of Internal Medicine, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
  2. 2Department of Hematology, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
  3. 3Department of Internal Medicine, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
  4. 4Department of Oncology, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
  1. Correspondence to Dr José Guilherme Freitas, jfrei1992{at}gmail.com

Summary

We report a case of a 90-year-old man with hypereosinophilia, lymphadenopathies and skin lesions, namely lichenification and pruritus. An aetiological investigation was performed, and a bone marrow (BM) biopsy and aspirate showed a hypercellular marrow with hypereosinophilia without dysmorphia or abnormal elements, and the BM and inguinal node’s immunophenotyping denied any presence of abnormal lymphoid cell population. The inguinal node biopsy revealed a multinodular proliferation of large cells S100 and CD1a+, and a diagnosis of Langerhans cell histiocytosis was made. The hypereosinophilia and skin lesions were managed with corticotherapy with substantial improvement of cutaneous lesions and lymphadenopathies and normalisation of eosinophil count. Finally, to define if it is a single or multisystem disease, a skin biopsy will be necessary.

  • haematology (incl blood transfusion)
  • malignant and benign haematology
  • medical management
  • dermatology

Statistics from Altmetric.com

Footnotes

  • Contributors JGF wrote the first concept of the manuscript. AJ, DR and JG critically revised it. After drafting the final version by JGF, all authors approved it for publication.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.