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Cortical laminar necrosis in a case of migrainous cerebral infarction
  1. Vikram Khardenavis1,
  2. Davala Krishna Karthik2,
  3. Sharvari Kulkarni3,
  4. Anirudda Deshpande4
  1. 1 Miraj Medical College, Miraj, Maharashtra, India
  2. 2 Department of Radiology, Surya Diagnostics, Warangal, Telangana, India
  3. 3 Maharashtra Institute of Medical Education and Research, Pune, Maharashtra, India
  4. 4 Department of Neurology, Vinayaka Neuro Multispecialty Clinic, Warangal, Telangana, India
  1. Correspondence to Dr Anirudda Deshpande, dr.anirudda.deshpande{at}


We report a 27-year-old woman, a known case of classical migraine headache, on oral contraceptive pills. She had a severe episode of migraine with visual aura attack, which continued late into the night. The next early morning, her headache persisted and she developed abrupt onset of dysarthria, right hemiparaesthesias. She attributed symptoms to her long-standing headache problem, and hence did not seek medical help for the next two weeks. The symptoms persisted despite her headache subsiding over the next 24 hours. She worsened 2 weeks later during another such episode of headache. This time, she developed right hemiparesis. The patient was admitted with provisional diagnosis of stroke. MRI of the brain showed left temporoparietal lesion and was radiologically compatible with cortical laminar necrosis.Extensive work-up was done to rule out other causes of young stroke. The patient improved with antiplatelets, antimigraine prophylaxis and stroke rehabilitation therapy.

  • headache (including migraines)
  • neuroimaging
  • stroke

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  • Contributors VK and DKK made substantial contributions to the conception and design of the work, acquisition, analysis and interpretation of the data. AD and SK was involved in drafting the work and revising it critically for important intellectual content. All authors approved the final version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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