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CASE REPORT
HHV-8-associated haemophagocytic lymphohistiocytosis in a patient with advanced AIDS
  1. Saroja Bangaru1,
  2. Amanda Strickland2,
  3. Dominick Cavuoti2,
  4. Nainesh Shah1
  1. 1Internal Medicine, University of Texas Southwestern, Dallas, Texas, USA
  2. 2Department of Pathology, University of Texas Southwestern, Dallas, Texas, USA
  1. Correspondence to Dr Saroja Bangaru, saroja.bangaru{at}phhs.org

Summary

We present a patient with advanced AIDS admitted with recurrent shock of unclear aetiology, fevers, altered mental status and refractory cytopenias. His case posed a diagnostic challenge because evaluation of septic shock in the setting of advanced AIDS requires a time-consuming work-up for broad infectious aetiologies that can delay consideration of other diagnoses, including primary or secondary haemophagocytic lymphohistiocytosis (HLH). After this patient did not improve with supportive care and empiric antimicrobials, there was concern for HLH given that he met ≥5 of the HLH consortium criteria. He underwent bone marrow biopsy, which was non-diagnostic. Empiric therapy for HLH was initiated, but unfortunately, the patient died. Autopsy revealed extensive haemophagocytosis in the spleen, bone marrow and liver, confirming the diagnosis of HLH. Postmortem, his soluble CD-25 returned 18 890 pg/mL (<1033 pg/mL), and his serum HHV-8 PCR resulted positive. The diagnosis was HLH secondary to Human Herpes Virus 8 (HHV-8) in a patient with advanced AIDS.

  • hiv / aids
  • malignant and benign haematology
  • pathology
  • haematology (incl blood transfusion)
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Footnotes

  • Contributors All authors were involved in the conception and design, acquisition and analysis of data, drafting the article or revising it critically for important intellectual content and gave final approval of the version published.

  • Competing interests None declared.

  • Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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