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Summary
Lymphoepithelioma-likethymic carcinoma is a rare neoplasm that presents with compressive symptoms or as an incidental radiological finding of an anterior mediastinal mass. It is an aggressive carcinoma with a high rate of invasion, metastasis and recurrence. Its diagnosis usually carries a poor prognosis largely due to propensity for late diagnosis. To date, guidance for treatment remains limited. This is a case of lymphoepithelioma-like thymic carcinoma in a young male adult who presented initially with back pain. Despite prompt initiation of chemotherapy with cisplatin, doxorubicin and cyclophosphamide, he had a complicated hospital course leading to demise within 2 months of diagnosis.
- Oncology
- Chemotherapy
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Footnotes
Contributors The following five coauthors are the sole authors of this case report. JMDG, the primary author, acquired data from patient on presentation. She wrote the clinical presentation and did extensive literature review on thymic carcinoma presentation and management, incorporating information in the discussion. She was part of the conceptualisation of the flow of the case. She took charge in critical revisions of the case and article formatting to BMJ guidelines. She obtained consent from the patient’s next of kin. She gave final approval of the version published. She will be responsible for overall content of the article as guarantor. GS analysed laboratory data in this patient, conducted an extensive literature review. Based on review of existing articles, she wrote the differential diagnoses section and contributed to the discussion and take-home messages sections of the article. She gave final approval of the version published. MLFCo was critical in coordination among different services (Radiology and Pathology departments) in obtaining relevant images and data for the case. He was active in critical revisions of the paper, including improvement of thought flow in the case presentation and discussion, addition of important content in the discussion as well as text and bibliography formatting. He gave final approval of the version published. MB was part of the conceptualisation and design of the case, identified parts of the case that need to be addressed. He drafted the treatment and outcomes section of the paper, and was integral in the critical revisions of the manuscript. He gave final approval of the version published. RA headed the conceptualisation and design of the case, and provided close supervision in the flow of the article. He assisted in obtaining relevant supplemental data for the case including pathology slides and radiological images; coordinated with both the Pathology and Radiology services. He guided the discussion points of the case. He revised the article critically for intellectual content. He gave final approval of the version published. All five authors were part of the direct clinical care of the patient during his hospital admission. All five authors agree to be accountable for the article and work to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.