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Long-term follow-up of hepatitis-associated aplastic anaemia
  1. Cristina Gonçalves,
  2. Sandra Ferreira,
  3. Susana Nobre,
  4. Isabel Gonçalves
  1. Unidade de Transplantação Hepática - PA, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal
  1. Correspondence to Dr Cristina Gonçalves, cristina.campos.goncalves{at}


Prognosis of hepatitis-associated aplastic anaemia (HAAA) was improved with haematopoietic stem cell transplantation (HSCT) and immunosuppression, but the long-term outcome remains undefined. Case 1: a girl aged 3 years with acute liver failure (ALF) submitted to orthotopic liver transplantation (OLT) subsequently developed aplastic anaemia and HSCT from a compatible sibling was performed. Post-HSCT, the patient developed post-transplant lymphoproliferative disorder and rituximab was administered with good response. Fifteen years later, both grafts show good outcome. Case 2: a girl aged 10 years submitted to OLT due to ALF, developed pancytopenia 2 months later. Due to the absence of a human leucocyte antigen compatible donor, she was treated with ciclosporin and antithymocyte globulin with very good long-term outcome. These clinical cases suggest that, for patients with HAAA that underwent OLT, aggressive therapy with HSCT or immunosuppression may provide a benign long-term outcome.

  • hepatitis other
  • malignant and benign haematology
  • transplantation
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  • Contributors All authors contributed to this paper. CG was involved in patient follow-up, acquisition of data and draft the paper; SF was involved in acquisition of data, patient follow-up and critical review of the paper; SN was involved in patient follow-up and critical review of the paper; IG was involved in patient follow-up, critical review of the paper and approved the final version.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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