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Interferon alpha-induced non-immune thyrotoxicosis treated by plasmapheresis
  1. Zeynel Abidin Sayiner1,
  2. Ayten Eraydın2,
  3. Taylan Metin2,
  4. Mesut Özkaya1
  1. 1Department of Endocrinology and Metabolism, Gaziantep University, Gaziantep, Turkey
  2. 2Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey
  1. Correspondence to Dr Zeynel Abidin Sayiner, zeynelasayiner{at}


Interferon-alpha (IFN-α) is an effective drug used for the treatment of chronic hepatitis C. So far its numerous side effects have been reported in the literature. It may be difficult to always put IFN-induced thyroid diseases into a single classic thyroid disease table. There are numerous atypical thyroid diseases due to IFN usage for hepatitis C virus. Herein, we present a case with a rare clinical table such as thyrotoxicosis observed following IFN-α therapy in a patient with euthyroid nodular thyroid without autoimmune thyroiditis findings and the use of therapeutic apheresis method for the treatment of disease.

  • thyroid disease
  • hepatitis c
  • unwanted effects / adverse reactions

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  • Contributors All authors: shared the responsibilities of the manuscripts writing process. ZAS: planning and conduct; acquisition of data or analysis and interpretation of data. ZAS, AE and TM: reporting. ZAS and MO: conception and design.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.