Article Text
Rare disease
CASE REPORT
Development of forced normalisation psychosis with ethosuximide
Summary
A 50-year-old man with known multidrug resistant coexistent focal and generalised epilepsy was commenced on ethosuximide, with normalisation of his electroencephalogram and cessation of absence seizures. Within 3 weeks, he developed a rapidly worsening paranoid psychosis with visual and olfactory hallucinations. A month after the cessation of ethosuximide and concurrent treatment with olanzapine, his psychosis resolved and permitted reinitiation of ethosuximide at a lower dose without recurrence of psychotic symptoms.
- epilepsy and seizures
- drugs: cns (not psychiatric)
- delusional disorder
- clinical neurophysiology