A 50-year-old man with known multidrug resistant coexistent focal and generalised epilepsy was commenced on ethosuximide, with normalisation of his electroencephalogram and cessation of absence seizures. Within 3 weeks, he developed a rapidly worsening paranoid psychosis with visual and olfactory hallucinations. A month after the cessation of ethosuximide and concurrent treatment with olanzapine, his psychosis resolved and permitted reinitiation of ethosuximide at a lower dose without recurrence of psychotic symptoms.
- epilepsy and seizures
- drugs: cns (not psychiatric)
- delusional disorder
- clinical neurophysiology
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Contributors SAM collected the patient data, performed the data review and composed the primary case report. FR-G provided the case, oversaw the case report write-up, and subsequently updated and corrected the drafts presented and offered expert advice.
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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