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Congenital scoliosis: an anomalous association with endosulfan
  1. Jayakrishnan Kelamangalathu Narayana Kurup,
  2. Simanchal P Mohanty
  1. Department of Orthopaedics, Kasturba Medical College, Manipal University, Manipal, India
  1. Correspondence to Dr Jayakrishnan Kelamangalathu Narayana Kurup, jkdoctorjk{at}


Endosulfan is an organochlorine pesticide that is used extensively across the world to kill insects. Incidence of acute and chronic toxicity with endosulfan poisoning has been reported, and nearly 80 countries have banned its use. However, it is still being used in many low-income/middle-income countries. One of the most severe tragedies because of endosulfan poisoning has taken place in the Indian state of Kerala due to persistent aerial spraying of endosulfan. Even though there are reports of skeletal and other congenital abnormalities in humans and experimental animals following exposure to endosulfan, very few have been documented. We report two cases of congenital scoliosis in siblings living in a community affected by high levels of endosulfan in the environment. High index of suspicion is essential during the screening of school children exposed to endosulfan. Congenital scoliosis is a progressive deformity that leads to severe disability, unless detected and corrected at an early stage.

  • poisoning
  • carcinogenesis
  • screening (oncology)
  • congenital disorders
  • disability
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  • Contributors Both authors contributed to conception and design of the paper. JKNK did the acquisition of data and drafting of the article. SPM made corrections to the final manuscript and was involved in the final approval of the version to be published.

  • Competing interests None declared.

  • Patient consent Guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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