Article Text

Download PDFPDF
Nodular pulmonary amyloidosis: a complex disease with malignancy association
  1. Jacob M Core1,
  2. Ali A Alsaad2,
  3. Liuyan Jiang3,
  4. Neal M Patel4
  1. 1Internal Medicine, Mayo Clinic Hospital Jacksonville, Jacksonville, Florida, USA
  2. 2Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA
  3. 3Pathology and Laboratory Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA
  4. 4Pulmonary and Critical Care, Mayo Clinic Florida, Jacksonville, Florida, USA
  1. Correspondence to Dr Ali A Alsaad, alsaad.ali{at}


Pulmonary amyloidosis is a rare disease that incorporates deposition of amyloid microfibril material in the lung parenchyma. The condition generally presents as an indolent subacute-to-chronic pulmonary disease and requires tissue biopsy to establish the diagnosis. Nodular pulmonary amyloidosis, a subtype of pulmonary amyloidosis, is characterised by special radiographic and pathological features. While the disease can be associated with inflammatory conditions; its association with mucosal-associated lymphoid tissue (MALT lymphoma) is unusual and carries management challenges. Herein, we illustrate a case study of nodular pulmonary amyloidosis associated with underlying MALT lymphoma in a patient with known systemic lupus erythematosus. The aim of this article is to share the management experience of this complex condition with the medical community and to conduct an up-to-date literature review on nodular pulmonary amyloidosis.

  • adult intensive care
  • respiratory medicine
  • interstitial lung disease
  • haematology (incl Blood Transfusion)
View Full Text

Statistics from


  • Contributors JMC and AAA authored the manuscript and conducted the literature review. AAA reviewed the final version of the manuscript for submission. AAA designed the figures and their legends. LJ interpreted the pathology images and critically reviewed the manuscript. NMP interpreted the chest images and critically reviewed the manuscript. All authors approved the final version of the manuscript prior to submission.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.