Article Text

Download PDFPDF
Successful twice interrupted therapy of HCV infection in patients with cirrhosis with hepatocellular carcinoma before and after liver transplantation
  1. Anna Szymanek-Pasternak1,2,
  2. Karolina Rostkowska1,2,
  3. Krzysztof Simon1,2
  1. 1Department of Infectious Diseases, Regional Specialistic Hospital, Wroclaw, Poland
  2. 2Department of Infectious Diseases and Hepatology, Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu, Wroclaw, Poland
  1. Correspondence to Professor Krzysztof Simon, krzysimon{at}


We are presenting the case study of the patient diagnosed at the age of 37 with liver cirrhosis due to genotype 1b hepatitis C virus infection. At the age of 46, he was diagnosed with hepatocellular carcinoma with subsequent resection of the tumour in May 2015. In December 2015, the treatment was started with ombitasvir, paritaprevir/ritonavir and dasabuvir (3D) with ribavirin (RBV) 1000 mg per day. After 24 days of this treatment, the patient received a deceased donor liver transplantation, followed by 18-day interruption of 3D therapy. Due to the anaemia, RBV dose was reduced to 600 mg per day for the rest of the treatment. At the 11th week of 3D+RBV treatment, there was another 8-day long discontinuation of therapy due to the postoperative wound infection. In total, the patient received 24 weeks of 3D+RBV treatment, achieving sustained virological response at week 24 post-treatment.

  • infections
  • hepatitis c
  • hepatitis and other GI infections
View Full Text

Statistics from


  • Contributors ASP collected the data, drafted and revised the paper. KR collected the data and revised the paper. KS revised the paper.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.