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Primary pericardial mesothelioma and asbestos exposure: a rare fatal disease
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  1. Diana Maria Monteiro Freitas1,
  2. Raquel L Ramos2,
  3. Luísa Serpa Pinto3,
  4. Rosa Ribeiro4
  1. 1 Internal Medicine, Hospital Geral de Santo Antonio SA, Porto, Portugal
  2. 2 Internal Medicine, Hospital Geral de Santo Antonio SA, Porto, Portugal
  3. 3 Internal Medicine, Hospital Geral de Santo Antonio SA, Porto, Portugal
  4. 4 Internal Medicine, Hospital Geral de Santo Antonio SA, Porto, Portugal
  1. Correspondence to Dr Diana Maria Monteiro Freitas, di.monteiro.freitas{at}gmail.com

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Description

A 73-year-old woman without a history of cardiovascular disease was admitted to the hospital with progressive dyspnoea on exertion during the past several weeks, bilateral lower extremity oedema, orthopnoea and paroxistic nocturnal dyspnoea. She lived a few metres away from a badly preserved building containing asbestos for 50 years. Estimated jugular venous pressure was 6+5 cm H2O, a pericardial friction rub was heard, bilateral basal lung crackles were present and symmetrical below-knee pitting oedema was seen. Probrain natriuretic peptide was 2304 pg/mL, and chest radiograph showed a globular cardiac silhouette and blunting of the costophrenic angles due to a small transudative pleural effusion containing benign mesothelial cells on cytological analysis. Transthoracic echocardiogram showed a large pericardial effusion with diastolic collapse of the right ventricle and a hypotransparent mass (4×1.6 cm) attached to the visceral pericardium in the right apex (video 1). Therapeutic pericardiocentesis was performed and cytological analysis of pericardial fluid demonstrated malignant cells of inconclusive origin. CT scan of the chest, abdomen and pelvis, mammography and upper and lower gastrointestinal endoscopies showed no evidence of extracardiac disease. A primary cardiac tumour was assumed and positron emission tomography-CT was done, as a part of the staging workup, demonstrating isolated hyperfixation in the apex and right atrium.

Video 1

Transthoracic echocardiogram showing a large circumferential pericardial effusion (PE) with right ventricular diastolic collapse and a hypotransparent mass (M) attached to the visceral pericardium in the right apex.

Four days after hospital admission, recurrent pericardial effusion was documented and pericardiectomy was undertaken. A primary pericardial malignant mesothelioma was diagnosed based on histological examination.

The patient was treated with carboplatin and pemetrexed experiencing disease progression and died 1 year after diagnosis.

Learning points

  • Primary pericardial malignant mesothelioma (PPMM) is an extremely rare tumour, with an incidence <0.002%. Besides, its insidious nature and the absence of specific clinical manifestation result in PPMM being often misdiagnosed as other forms of pericardial disease, and antemortem diagnosis is infrequent.1

  • Due to the absence of a premalignant lesion, late presentation and few treatment approaches, PPMM carries a poor prognosis and its outcome is uniformly fatal, with a mean survival time of 6–10 months from diagnosis.2

  • Risk factors include simian virus 40 infection, radiation exposure, thorotrast, tuberculosis and exposure to non-asbestos materials such as erionite.2 We emphasise the exposure to asbestos in this case, an association that remains controversial in the literature and that has rarely been reported in the absence of concomitant pleural disease.3

References

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Footnotes

  • Contributors All authors contributed substantially to the conception of this manuscript. DMMF and RLR were responsible for reporting the case. DMMF, RLR and LSP wrote the learning points and performed the bibliographic research. DMMF had full responsibility for the final work.

  • Competing interests None declared.

  • Patient consent Obtained from next of kin.

  • Provenance and peer review Not commissioned; externally peer reviewed.