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Aripiprazole-induced hypersensitivity pneumonitis
  1. Kulothungan Gunasekaran1,
  2. Swetha Murthi2,
  3. Jeffrey Jennings3,
  4. Nazir Lone4
  1. 1 Henry Ford Health System, Detroit, USA
  2. 2 Internal Medicine, Sinai Grace Hospital, Detroit, USA
  3. 3 Division of Pulmonary and Critical Care, Henry Ford Health System, Detroit, USA
  4. 4 Internal Medicine, Pulmonary and Critical Care, Bassett Healthcare, Cooperstown, USA
  1. Correspondence to Dr Kulothungan Gunasekaran, stankuloth{at}


Aripiprazole is an atypical antipsychotic agent commonly used in the management of schizophrenia. Aripiprazole has not been reported to have an association with interstitial lung disease. We describe a case of a 36-year-old woman who began to experience respiratory issues shortly after starting aripiprazole and presented to us 4 years later with progressive exertional shortness of breath. High-resolution CT of the chest showed a bilateral ground glass pattern. Video-assisted thoracoscopy with biopsy revealed alveolar septal thickening and an inflammatory infiltrate composed mainly of lymphocytes, suggestive of chronic hypersensitivity pneumonitis. After discontinuing aripiprazole and initiating prednisolone therapy, the patient’s pulmonary symptoms improved. This case highlights that aripiprazole can cause hypersensitivity pneumonitis in susceptible individuals.

  • psychiatry (drugs and medicines)
  • exposures
  • unwanted effects / adverse reactions
  • interstitial lung disease

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  • Contributors KG, the primary author, was responsible for data acquisition, analysis, interpretation and manuscript preparation. SM participated in manuscript preparation and edition. JJ supervised development of the manuscript and final evaluation. NL participated in data interpretation and manuscript evaluation. All authors read and approved the final version of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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