Article Text

Download PDFPDF
Contribution of arterial spin-labelling MRI in a case with immune reconstitution inflammatory syndrome
  1. Noriaki Wada1,
  2. Tomoyuki Noguchi1,
  3. Takahiro Aoki2,
  4. Tsuyoshi Tajima1
  1. 1Department of Radiology, Kokuritsu Kokusai Iryo Center Byoin, Shinjuku-ku, Tokyo, Japan
  2. 2Department of AIDS Clinical Center, Kokuritsu Kokusai Iryo Center Byoin, Shinjuku-ku, Tokyo, Japan
  1. Correspondence to Dr Noriaki Wada, nontaro1717{at}


Central nervous system immune reconstitution inflammatory syndrome (CNS-IRIS), which occurs most often in HIV-infected patients, is an exacerbation of inflammatory reactions related to opportunistic infections as well as primary CNS malignancies both of which mostly occur in HIV-infected patients. However, differential diagnoses are challenging both clinically and radiologically. We describe a patient with CNS-IRIS due to toxoplasmosis whose 11C-methionine uptake suggested lymphoma but whose arterial spin-labelling MRI led to the correct diagnosis.

  • Radiology
  • Neuroimaging

Statistics from


  • Contributors NW wrote the manuscript. TN analysed MRI, ASL-MRI and MET-PET of this case and contributed to writing the manuscript. TA was an attending doctor of the patient and contributed to writing the manuscript. TT contributed to writing the manuscript. All the authors read, reviewed and approved the final version of this case report.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.