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Recurrence of immature ovarian teratoma as malignant follicular carcinoma with liver and peritoneal metastasis 22 years after completion of initial treatment
  1. Nicholas Brian Shannon1,
  2. Norman Hok Ling Chan2,
  3. Melissa Ching Ching Teo3
  1. 1Department of General Surgery, Singapore General Hospital, Singapore
  2. 2Department of Pathology, Singapore General Hospital, Singapore
  3. 3Division of Surgical Oncology, National Cancer Centre Singapore, Singapore
  1. Correspondence to Dr Melissa Ching Ching Teo, melissa.teo.c.c{at}


Growing tumour syndrome (GTS) is a rare event in which germ cell tumours treated with chemotherapy undergo maturation, acquire resistance to chemotherapy and regrow. The optimum treatment strategy is complete surgical excision. We report on a case of GTS with malignant metastases to the liver presenting 22 years after completion of treatment for immature teratoma, successfully managed with surgical resection alone.

  • oncology
  • gynecological cancer

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  • Contributors All of the authors have participated in the research design, analysing of data and writing of the paper. The authors have reviewed the manuscript and approved it for submission. NBS participated in writing the article and received informed consent from the patient. NHLC is responsible for histological review and diagnosis and critically revised the article. MT is responsible for surgical care of the patient and critically revised the article.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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