Article Text

Download PDFPDF
Novel variant of common variable immunodeficiency
  1. Eileen Conaway1,2
  1. 1Graduate Medical Education, Florida Hospital East Orlando, Orlando, Florida, USA
  2. 2Nova Southeastern University, Fort Lauderdale, Florida, USA
  1. Correspondence to Dr Eileen Conaway, econawaydo{at}


A 57-year-old woman with frequent respiratory infections was initially diagnosed with IgG subclass deficiency based on low levels of IgG subclasses 2 and 3. Three years later, she progressed to having IgA deficiency as well. With a normal total IgG level, she does not meet criteria for common variable immunodeficiency (CVID). This may represent a variant of CVID. This also highlights the importance of immunoglobulin subclass estimation in patients where immunodeficiency is suspected clinically. She is being treated with rotational antibiotics the first 10 days of every month, monthly intravenous immunoglobulin (IVIG) infusion and osteopathic manipulation one to two times per month. On this regimen, although she has had several viral respiratory infections, she has avoided further hospitalisation for more than 1 year.

  • Immunology
  • Pneumonia (infectious disease)
  • Complementary medicine

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors EC is the sole author.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.