Article Text

Download PDFPDF
Modafinil in schizophrenia: is the risk worth taking?
  1. Daniel Neto1,2,
  2. Carla Spínola1,
  3. Joaquim Gago1,2
  1. 1Departamento de Psiquiatria e Saúde Mental, Centro Hospitalar de Lisboa Ocidental, Lisboa, Portugal
  2. 2Departamento de Saúde Mental, NOVA Medical School – Faculdade de Ciências Médicas, Lisboa, Portugal
  1. Correspondence to Dr Daniel Neto, danielcarvalhoneto{at}


Schizophrenia is a severe mental disorder characterised by positive and negative symptoms. Negative symptoms are difficult to treat and there is no specific treatment. In small trials, modafinil has been studied in association with antipsychotic treatment. We present three cases of its use; two have developed positive symptoms and one developed renal impairment. Further studies are needed to assess its usefulness in schizophrenia and safety in this group of patients.

  • drugs: psychiatry
  • schizophrenia

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors DN and JG were responsible for planning, conduct, reporting, conception and design. CS was responsible for reporting.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.