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Seizure induced by sudden cessation of pregabalin in a patient with chronic kidney disease
  1. Yang Timothy Du1,2,
  2. Anthony P Roberts1,2,
  3. David J Torpy1,2
  1. 1 Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
  2. 2 Discipline of Medicine, The University of Adelaide, Adelaide, Australia
  1. Correspondence to Dr Yang Timothy Du, yang.timothy.du{at}


A middle-aged woman with diabetic nephropathy on pregabalin for neuropathic pain presented with a diarrhoeal illness. She was found to have acute on chronic renal impairment with an estimated glomerular filtration rate (eGFR) of 10 mL/min, and her usual 150 mg/day of pregabalin was abruptly ceased. Although renal recovery to her baseline of eGFR 15 mL/min was achieved within 3 days, her pregabalin was not restarted. She suffered a tonic–clonic seizure 4 days later, thought to be due to pregabalin withdrawal as there were no other likely causes identified. She suffered no further seizures on recommencement of pregabalin at a renally adjusted dose of 75 mg/day.

  • Contraindications and precautions
  • Neurology (drugs and medicines)
  • Endocrine system
  • Renal system

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  • Contributors YTD and DJT were responsible for substantial contributions to the conception and design, analysis and interpretation of data.

    YTD was responsible for the acquisition of data.

    YTD, DJT and APR were responsible for drafting the article and revising it critically for important intellectual content.

    YTD, DJT and APR gave final approval of the version published.

    YTD, DJT and APR agree to be accountable for the article and to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.