Article Text

Download PDFPDF
An unusual case of Escherichia coli O157:H7 infection with pseudomembranous colitis-like lesions associated with haemolytic-uraemic syndrome and neurological sequelae
  1. James Kennedy1,
  2. Lauren Simmonds2,
  3. Robert Orme2,
  4. Warren Doherty2
  1. 1Department of Intensive Care, Cheltenham General Hospital, Cheltenham, UK
  2. 2Department of Anaesthetics, Cheltenham General Hospital, Cheltenham, UK
  1. Correspondence to Dr James Kennedy, james{at}


A 75-year-old man was admitted with abdominal pain and fresh rectal bleeding. Significantly, he had no risk factors for Clostridium difficile infection. An abdominal CT demonstrated colonic thickening, and flexible sigmoidoscopy identified pseudomembranous colitis-like lesions. After initial treatment as C. difficile colitis, a stool sample revealed Escherichia coli O157:H7 infection. Antibiotic therapy was stopped due to the risk of lysis-mediated toxin release, but unfortunately, the patient continued to deteriorate. He developed several of the severe sequelae of E. coli O157:H7 infection, including haemolytic-uraemic syndrome with an acute kidney injury necessitating haemofiltration, plus progressively severe seizures requiring escalating antiepileptic treatment and intubation for airway protection. After a prolonged intensive care admission and subsequent recovery on the ward, our patient was discharged alive.

  • infection (gastroenterology)
  • endoscopy
  • epilepsy and seizures
  • acute renal failure

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors JK authored the majority of the text and was involved in data acquisition. LS acquired and interpreted data and wrote the investigations section. RO and WD critically revised the article and gave final approval to its publication.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.