Article Text

Small lymphocytic lymphoma with Reed Sternberg cells: a diagnostic dilemma
  1. S Pervez,
  2. B Abro,
  3. H Shahbaz
  1. Department of Pathology and Laboratory Medicine, Aga Khan University Hospital Karachi, Karachi, Sindh, Pakistan
  1. Correspondence to Professor S Pervez, shahid.pervez{at}


Reed Sternberg (RS) cells in the setting of small lymphocytic lymphoma (SLL) can complicate the histopathological diagnosis. We report a case of a man aged 54 years who presented with cervical lymphadenopathy. Resection of the lymph node was performed and sent for histopathological evaluation to a local laboratory. A diagnosis of SLL with Classic Hodgkin's lymphoma (CHL) was made. The medical oncologist who encountered this diagnosis for the first time sent the biopsy blocks to our laboratory for a second opinion. On review of the biopsy and immunohistochemical stains, it showed typical SLL morphology and immunophenotype. Focally, it showed large mononuclear RS type cells; however, no typical background of CHL was seen. The diagnosis was revised to ‘SLL with RS like cells with no convincing evidence of CHL’. The patient was subsequently treated as a case of SLL and no progression was observed on a follow-up of 5 years.

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  • Contributors The corresponding author diagnosed and identified the case. BA and HS searched the literature and wrote the manuscript under the guidance of the corresponding author.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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