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Collapsing glomerulopathy in systemic lupus erythematosus
  1. Kerolos Abadeer1,
  2. Ali A Alsaad2,
  3. Xochiquetzal J Geiger3,
  4. Ivan E Porter4
  1. 1Department of Nephrology and Hypertension, Mayo Clinic Florida, Jacksonville, Florida, USA
  2. 2Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA
  3. 3Department of Pathology and Laboratory Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA
  4. 4Department of Nephrology and Hypertension, Mayo Clinic, Jacksonville, Florida, USA
  1. Correspondence to Dr Ali A Alsaad, alsaad.ali{at}


Collapsing glomerulopathy (CG) is a rare disease that can be associated with multiple other disorders. It usually leads to poor prognosis with a high percentage of patients progressing to end-stage renal disease. In this article, we illustrate a clinical case of CG associated with systemic lupus erythematosus that had a prompt response to mycophenolate and prednisone. The condition started after sudden cessation of the already established mycophenolate treatment regimen. The patient then presented with acute kidney injury due to kidney biopsy-proven CG. In that circumstance, we hypothesised that mycophenolate may play a role in prevention and development of CG.

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  • Contributors KA and AAA wrote the manuscript. XJG provided the pathology images and its interpretation. IEP critically reviewed the manuscript. AAA reviewed and coordinated the submission and manuscript revision process. All authors approved the manuscript before submission.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.