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Squamous cell carcinoma of the extrahepatic bile duct with metachronous para-aortic lymph node metastasis successfully treated with S-1 plus cisplatin
  1. Ryohei Nishiguchi1,
  2. Dal Ho Kim2,
  3. Masayuki Honda2,
  4. Tsuguo Sakamoto2
  1. 1Department of Surgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan
  2. 2Department of Surgery, Sainokuni Higashi Omiya Medical Center, Saitama, Japan
  1. Correspondence to Dr Ryohei Nishiguchi, ryoheisu{at}


The most common histological classification of bile duct cancer is adenocarcinoma and squamous cell carcinoma (SCC) is relatively rare. We report a case of a 78-year-old man with SCC of the extrahepatic bile duct associated with metachronous para-aortic lymph node metastasis. He had undergone subtotal stomach-preserving pancreatoduodenectomy. The pathological findings demonstrated moderately differentiated SCC of the distal extrahepatic bile duct (T1N1M0, stage IIB). 6 months after surgery, recurrence of the para-aortic lymph node was shown in abdominal CT. 5 courses of tegafur/gimeracil/oteracil (S-1) plus cisplatin therapy was performed and the para-aortic lymph node disappeared, confirmed as complete response by imaging findings. The patient is alive without recurrence, 10 months after recurrence and chemotherapy.

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  • Contributors RN drafted the manuscript. DHK was operator of the patient. DHK and MH revised the manuscript and TS has approved the final manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.