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Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction
  1. Adam Baghban1,
  2. Marwan Mikheal Azar2,
  3. Raffaele Mario Bernardo1,
  4. Maricar Malinis1,3
  1. 1Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA
  2. 2Department of Pathology, Section of Microbiology, Massachusetts General Hospital, Boston, Massachusetts, USA
  3. 3Department of Surgery, Section of Transplantation, Yale University School of Medicine, New Haven, Connecticut, USA
  1. Correspondence to Dr Adam Baghban; adam.baghban{at}


Mycobacterium tuberculosis presents unique challenges in the peritransplant period. Here, we describe a case of disseminated tuberculosis following renal transplantation with alemtuzumab induction immunosuppression in a patient with remotely treated pulmonary tuberculosis and ongoing risk factors for re-infection. We also review the available literature regarding the prevalence of tuberculosis infection following solid organ transplant and management of high-risk patients, including the role for isoniazid preventative therapy.

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  • Contributors AB contributed to review of literature and drafting of the manuscript. MMA, RMB and MM contributed to critical review and editing of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.