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Minimal change disease associated with malignant pleural mesothelioma: case report and review of the literature
  1. Halil Yildiz1,
  2. Stoian Ioana Andreea2,
  3. Delphine Hoton3,
  4. Jean Cyr Yombi4
  1. 1Department of Medecine Interne, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
  2. 2Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
  3. 3Department of Anatomopathology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
  4. 4Department of Internal Medicine and Perioperative Medicine, Catholic Univ Louvain, Brussels, Belgium
  1. Correspondence to Dr Halil Yildiz, halil.yildiz{at}


A 77-year-old man with a history of asbestos exposure was admitted to our internal medicine division for generalised weakness, fatigue, loss of weight, night sweats and difficulty for breathing since 3 months. Clinical examination revealed left fine crackles and bilateral leg oedema. Blood test showed elevated C reactive protein level at 142 mg/L, lactate dehydrogenase level at 421 UI, creatinine level at 5.75 mg/dL. Serum albumin level at 30 g/L, urinalysis showed significant proteinuria at 6.4 g/L. Chest X-ray showed left pleural effusion. Renal ultrasonography was normal. Thoracic CT and positron emission tomography showed mediastinal enlargement with lymphadenopathies and left pleural effusion and thickening. A pleural biopsy showed features compatible with malignant epithelioid mesothelioma. Renal biopsy showed minimal change disease and acute tubular necrosis. A diagnosis of malignant mesothelioma associated with minimal change disease and acute tubular necrosis secondary was then made. Given the poor general condition, palliative care was initiated and the patient died from respiratory failure 3 months later.

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  • Contributors HY and JCY provided clinical care to the patient and contributed equally to the writing of this paper. DH helped to analyse the anatomopathological features of kidney and pleural biopsies. SIA helped to analyse the CT and PET-CT scans. All the authors have seen and approved the final version. HY accepts responsibility for the overall content as a guarantor.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.