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Successful improvement of Buschke-Löwenstein tumour in an HIV-infected patient with antiretroviral therapy alone
  1. Camille Grodner1,
  2. Aurélia Henn1,2,
  3. Jean-Daniel Lelièvre1,2,
  4. Sébastien Gallien1,2
  1. 1Hopitaux Universitaires Henri Mondor, Creteil, France
  2. 2Universite Paris-Est Creteil Val de Marne Faculte de medecine, Creteil, France
  1. Correspondence to Dr Sébastien Gallien, sebastien.gallien{at}


Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated immunodeficient patients. Different therapeutic options, alone or in combination, have been reported for the treatment of BLT including local therapy but wide surgical local excision is however recommended as the most important therapeutic intervention. We report a case of a HIV-infected man who developed a voluminous pelvic BLT which disappeared progressively under antiretroviral therapy with no additional treatment, contemporary to an improvement of his immunity, highlighting the possible spontaneous reversibility of HPV-induced tumours in treated HIV infection.

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  • Contributors CG, AH, J-DL and SG were in charge of the care of the patient and were responsible for the acquisition of data. CG and SG were responsible for the study concept and design and drafted the manuscript. CG, AH, J-DL and SG performed critical revisions of the manuscript for important intellectual content. SG was responsible for study supervision.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.