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CASE REPORT
Rapidly progressing dual infection with Aspergillus and Rhizopus: when soil inhabitants become deadly invaders
  1. Milind Bhagat1,
  2. Alwyn Rapose2
  1. 1Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA
  2. 2Department of Infectious Diseases, Reliant Medical Group and Saint Vincent Hospital, Shrewsbury, Massachusetts, USA
  1. Correspondence to Dr Alwyn Rapose, alwyn.rapose{at}gmail.com

Summary

We present a case report of a 61-year-old patient with acute pulmonary and cerebral infections with Aspergillus and Rhizopus. The only risk factor for invasive fungal disease was high-dose corticosteroids used to treat her chronic obstructive pulmonary disease exacerbation. She had rapid progression and succumbed to her infections within 2 weeks of diagnosis in spite of aggressive antifungal therapy and surgery. To the best of our knowledge, this is the first reported case of rapidly fatal dual infection with Aspergillus and Rhizopus. Our case highlights the role of high-dose corticosteroids as a risk factor for invasive fungal disease in patients without traditional risk factors like haematological malignancies, solid organ transplantation or uncontrolled diabetes.

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Footnotes

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.