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Takotsubo cardiomyopathy with use of salbutamol nebulisation and aminophylline infusion in a patient with acute asthma exacerbation
  1. Yousuf Hasan Khwaja,
  2. Javed Majid Tai
  1. Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
  1. Correspondence to Dr Yousuf Hasan Khwaja, yousuf.hasan{at}


Takotsubo cardiomyopathy, apical ballooning syndrome or stress-induced cardiomyopathy is characterised by transient left ventricular dysfunction, mimicking myocardial infarction in the absence of obstructive coronary artery disease or acute plaque rupture on coronary angiography. The exact mechanism of myocardial dysfunction in Takotsubo cardiomyopathy is unknown; however, due to its association with physical and emotional stress, it is postulated that catecholamines play a central role in its pathogenesis. We present a case of a patient who was admitted with acute asthma exacerbation and was treated with β-2 agonist nebulisation and intravenous aminophylline. During her hospital stay she developed Takotsubo cardiomyopathy.

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  • Contributors The patient was admitted under care of JMT (Assistant Professor and Consultant Interventional cardiologist). The coronary angiogram was performed by JMT. YHK assisted JMT in performing the coronary angiogram. He was actively involved in the management of the patient while she was admitted under JMT service in the coronary care unit and while in the special care unit. The coronary angiogram and echocardiogram was reported by JMT. The case report was written by YHK under supervision of JMT. The literature search, designing and formulation of the case report was done by YHH. JMT did the final editing of the case report for submission.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.