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Castleman's disease in carcinoma gall bladder
  1. Vijay Waman Dhakre1,
  2. Sanjay Nagral2,3,
  3. Aditya Jayesh Nanavati3
  1. 1Department of Surgical Gastroenterology, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India
  2. 2Department of Gastrointestinal Surgery, Jaslok Hospital, Mumbai, Maharashtra, India
  3. 3Department of General Surgery, K B Bhabha Municipal General Hospital, Mumbai, Maharashtra, India
  1. Correspondence to Dr Vijay Waman Dhakre, vddrvijayd{at}


Castleman's disease (CD) also known as angiofollicular lymph node hyperplasia represents a group of uncommon non-clonal lymphoproliferation. We herein report a case of CD associated with carcinoma of the gall bladder. To the best of our knowledge, it is the first of its kind and has not been reported in the past. The hypothesis regarding the aetiopathogenesis of CD is that it is associated with interleukin-6 surges. This may be explained by the overproduction of IL-6 by tumour cells or IL-6 production due to a long-standing/smouldering localised inflammatory response. An important question raised by this observation is whether the finding of CD has any effect on the outcome of this patient of carcinoma of the gall bladder. Further research is required in this matter.

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  • Contributors VWD designed the article, procured details of case, formulated the figures in this article and outlined the hypothesis based on existing literature. AJN contributed in drafting and making necessary additions in discussion and verification of the articles. SN had finalised the draft and made appropriate corrections in the final article.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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