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Indications for antiviral therapy for chronic hepatitis B in pregnant mothers
  1. Eric Raeyoon Yoo1,
  2. Ryan Babu Perumpail2,
  3. George Cholankeril3,
  4. Aijaz Ahmed2
  1. 1Department of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA
  2. 2Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA
  3. 3Division of Gastroenterology and Hepatology, University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee, USA
  1. Correspondence to Dr Aijaz Ahmed, aijazahmed{at}


The use of antiviral therapy for chronic hepatitis B virus (HBV) infection in the setting of pregnancy needs to be individualised based on limited data. We report a case of a 34-year-old Korean-American woman with a history of pregnancy with emergent caesarean section due to prolonged labour in the setting of HBV e-antigen (HBeAg) positive chronic HBV with a pretreatment baseline HBV DNA level of 110000 000 million copies per mL. Her first delivery was complicated by mother-to-child transmission (MTCT) of HBV infection to her daughter despite standard active and passive immunoprophylaxis. Our case report highlights an important clinical decision-making step regarding the timing of antiviral therapy in the management of chronic HBV in pregnant women with high risk of MTCT.

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  • Contributors ERY contributed to case report concept and design; acquisition of data; analysis and interpretation of data and drafting of the initial and final manuscript. RBP and GC contributed to case report concept and design; interpretation of data; drafting of the manuscript and critical revision of the manuscript. AA contributed to case report concept and design; analysis and interpretation of data; drafting of the manuscript; critical revision of the manuscript and case report supervision.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.