Article Text

Download PDFPDF
Complete androgen insensitivity syndrome with concomitant seminoma and Sertoli cell adenoma: an unusual combination
  1. Balamurugan Thirunavukkarasu1,
  2. Asit Ranjan Mridha1,
  3. Neena Malhotra2,
  4. Sheragaru Hanumanthappa Chandrashekhara3
  1. 1Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
  2. 2Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India
  3. 3Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Dr Asit Ranjan Mridha, asit_aiims{at}


Androgen insensitivity syndrome is a rare disorder of sex development and its clinical manifestations vary from subtle male infertility to an overt complete androgen insensitivity syndrome (CAIS) with a female phenotype. CAIS is often diagnosed at puberty or in adolescence during investigation for primary amenorrhoea. Undiagnosed patients have an increased risk of development of malignancy in the harboured testes. Inguinal hernia is the commonest mode of presentation of CAIS in childhood and various screening methods are available during the initial herniorrhaphy procedure. Controversy exists in the need to screen and the methods of screening in all cases of premenstrual girls with inguinal hernia. Abnormal observation in a suspicious case requires karyotyping for confirmation. We describe a case of CAIS with simultaneous presence of seminoma and a Sertoli cell adenoma in a 17-year-old patient who had a history of surgery for inguinal hernia at age of 5 years.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors BT and ARM were involved in conception, designing and critical review of the manuscript and were responsible for overall supervision. NM provided clinical details and treated the patient. SHC provided radiological details.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.