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CASE REPORT
Cotrimoxazole treats fluoroquinolone-resistant Salmonella typhi H58 infection
  1. Manan Karki1,
  2. Sarbagya Pandit1,
  3. Stephen Baker2,
  4. Buddha Basnyat1
  1. 1Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal
  2. 2Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
  1. Correspondence to Professor Buddha Basnyat, buddha.basnyat@ndm.ox.ac.uk.

Summary

A woman aged 20 years presented with fever and no localising signs. She was treated with cotrimoxazole and the subsequent blood culture was positive for Salmonella typhi (S. typhi), which was resistant to fluoroquinolones but susceptible to cotrimoxazole. Genotyping identified an FQ-R subclade of H58 S. typhi. Fever clearance time was 4 days after starting the antibiotics, and no relapses were noted on 2 months of follow-up. This inexpensive, well-known and easily available antimicrobial could be suitably redeployed for fluoroquinolone-resistant enteric fever in South Asia.

https://doi.org/10.1136/bcr-2016-217223

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    Footnotes

    • Contributors MK and SP took care of the patient. SB helped with the isolation of the organism and subsequent diagnosis. BB conceived the idea and supervised the patient care. All helped with the write up and approval of the final manuscript.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.