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CASE REPORT
LGI1 encephalitis: a disease of jerks and confusion
  1. Deepa Dash1,
  2. Madhavi Tripathi2,
  3. Kavish Ihtisham3,
  4. Manjari Tripathi3
  1. 1AIIMS, Delhi, India
  2. 2Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
  3. 3Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
  1. Correspondence to Professor Manjari Tripathi, manjari2tripathi{at}gmail.com

Summary

Limbic encephalitis is a group of immune-mediated disorders that includes the classic paraneoplastic encephalitic syndrome and the recently described non-paraneoplastic autoimmune encephalitis most of which target the extracellular antigens. We present a case of 70-year-old man who presented with rapidly progressive cognitive decline and refractory faciobrachial dystonic seizures and demonstrated seropositivity for leucine-rich, glioma-inactivated protein 1 antibodies. After immunomodulation, the patient had dramatic improvement in the cognitive functioning and in seizure control.

https://doi.org/10.1136/bcr-2016-217083

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    Footnotes

    • Contributors All of the authors agree to the order of authorship and have contributed in the following aspect of the article. DD, KI and MT participated in data collection. DD drafted the article. MT critically revised the article. MT provided final approval of the version to be published.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.