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Partial interhemispheric disconnection syndrome (P-IHDS) secondary to Marchiafava-Bignami disease type B (MBD-B)
  1. Carlo Canepa1,
  2. Lorena Arias2
  1. 1Department of Stroke and Neurology, James Paget University Hospital, Great Yarmouth, Norfolk, UK
  2. 2James Paget University Hospitals NHS Foundation Trust, Great Yarmouth, Norfolk, UK
  1. Correspondence to Dr Carlo Canepa, Neurocanepa{at}


A 53-year-old man with a 35-year history of excessive alcohol intake presents to our neurology department with 4-year history of progressive neurocognitive deterioration and disconnection syndrome. MRI head demonstrates extensive demyelination of the corpus callosum (and of extracallosal sites as well), leading to a diagnosis of Marchiafava-Bignami disease. He was given treatment with vitamin B complex (including folate) and was assessed and managed by psychology, occupational therapy and physiotherapy with initial signs of improvement.

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  • Contributors CC and LA involved in the clinical evaluation, investigation request, diagnosis and management of the patient. Furthermore, the patient has been followed up in our trust by a team of dedicated physiotherapists, occupational therapists, speech and language therapists and psychologists. The major contributors to the planning, conduct and reporting of the case were CC and LA.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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