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Repeated failed non-invasive prenatal testing in a woman with immune thrombocytopenia and antiphospholipid syndrome: lessons learnt
  1. C Y Y Hui,
  2. W C Tan,
  3. E L Tan,
  4. L K Tan
  1. Department of Obstetrics and Gynaecology, Singapore General Hospital, Singapore, Singapore
  1. Correspondence to Dr C Y Y Hui, celenehui{at}


We present a case of a 37-year-old Chinese woman (gravida 4 para 0) with a history of immune thrombocytopenia and type IIb antiphospholipid syndrome. She was started on 100 mg of aspirin, 20 mg of prednisolone and 20 mg of subcutaneous low-molecular-weight heparin daily for her fourth pregnancy. She opted for non-invasive prenatal testing for aneuploidy screening but had failed results three times consecutively from insufficient fetal cfDNA initially or high variance in cfDNA counts on redraws. She declined invasive karyotyping. Her pregnancy was complicated by severe pre-eclampsia and fetal growth restriction at 19+6 weeks of gestation and was terminated. Subsequent fetal karyotyping revealed a normal karyotype of 46XY with no apparent abnormalities.

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  • Contributors LKT involved in conception, revising and finalising the manuscript. WCT and ELT involved in revising the manuscript. CYYH involved in drafting, revising and finalising the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.