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Rare case of glioblastoma multiforme located in posterior corpus callosum presenting with depressive symptoms and visual memory deficits
  1. Hale Yapıcı-Eser1,
  2. Aslıhan Onay2,
  3. Özgür Öztop-Çakmak3,
  4. Emrah Egemen4,
  5. Ebru Nur Vanlı-Yavuz3,
  6. İhsan Solaroğlu5
  1. 1Department of Psychiatry, Koç Universitesi, School of Medicine, Istanbul, Turkey
  2. 2Department of Radiology, Koç University Hospital, İstanbul, Turkey
  3. 3Department of Neurology, Koç University Hospital, İstanbul, Turkey
  4. 4Department of Neurosurgery, Koç University Hospital, İstanbul, Turkey
  5. 5Department of Neurosurgery, Koç University, School of Medicine, İstanbul, Turkey
  1. Correspondence to Dr Hale Yapici Eser, hyapici{at}


Most of the primary brain tumours are located in the supratentorial region, and it is uncommon to see tumour growth on deep brain structures such as posterior corpus callosum (PCC). In addition, lesions in PCC are also difficult to recognise, because construction apraxia, visuospatial perception and attentional capacity impairment may be the only presenting symptoms. Here, we represent a rare case of gliobastoma multiforme located in PCC, which solely presents with depressive symptoms and visual memory deficits. Initial manifestations of primary brain tumours with psychiatric symptoms and memory disturbances, in addition to headaches and seizures, should be kept in mind.

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  • Contributors HYE performed the patient's psychiatric interview and also collateral interview with the family for additional information, wrote the first draft of the article and is responsible for the overall content. AO has evaluated the radiological images and contributed mainly to the discussion of the GBM localisation and its cystic formation. ÖÖ-Ç performed the neurological examination and ENVY has applied the neuropsychiatric test battery. EE and IS have evaluated the patient from the neurosurgical point of view and performed the neurosurgery. All authors contributed significantly to the discussion of the patient and revising of the first draft. All authors approved the final article and assured all the questions regarding the accuracy of the article.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.