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CASE REPORT
Rare allergic reaction of the kidney: sitagliptin-induced acute tubulointerstitial nephritis
  1. Ali A Alsaad1,
  2. Sarah M Dhannoon2,
  3. Sally-Ann L Pantin3,
  4. Ivan E Porter4
  1. 1Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA
  2. 2Department of Internal Medicine, University of Central Florida, Orlando, Florida, USA
  3. 3Department of Family Medicine, Mayo Clinic, Jacksonville, Florida, USA
  4. 4Department of Nephrology, Mayo Clinic, Jacksonville, Florida, USA
  1. Correspondence to Dr Ali A Alsaad, alsaad.ali{at}mayo.edu

Summary

A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case.

https://doi.org/10.1136/bcr-2016-216297

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