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Histological transformation from non-small cell to small cell lung carcinoma
  1. Yuki Haruta(Inoue)1,
  2. Yuki Kataoka2,
  3. Junichi Nikaido2,
  4. Naoki Nakajima3
  1. 1Chubu Rosai Byoin, Nagoya, Japan
  2. 2Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo, Japan
  3. 3Department of Diagnostic Pathology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyogo, Japan
  1. Correspondence to Dr Yuki Haruta(Inoue), gamann92{at}gmail.com

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A 58-year-old woman with no history of smoking was admitted to our hospital with exacerbation of cough. CT of the chest revealed a left upper lobe lung tumour. Bronchoscopic biopsy of the tumour revealed stage IV poorly differentiated adenocarcinoma (figure 1) with epidermal growth factor receptor (EGFR) gene mutation (L858R point mutation). After cytotoxic chemotherapy (cisplatin and pemetrexed) as first-line therapy, disease progression was identified. For …

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