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Leydig cell tumour and mature ovarian teratoma: rare androgen-secreting ovarian tumours in postmenopausal women
  1. Ana Palha1,
  2. Luísa Cortez1,
  3. Ana Paula Tavares2,
  4. Ana Agapito1
  1. 1Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal
  2. 2Department of Surgery, Centro Hospitalar Lisboa Central, Lisbon, Portugal, Centro Hospitalar de Lisboa Central, Lisboa, Lisboa, Portugal
  1. Correspondence to Dr Ana Palha anamfpalha{at}


Androgen-secreting ovarian tumours are extremely rare accounting for <5% of all ovarian neoplasms. They are more frequent in postmenopausal women and should be suspected in the case of a rapid onset of androgenic symptoms. We report 4 cases of postmenopausal women who presented with signs of virilisation. All patients revealed increased serum levels of testosterone, normal dehydroepiandrosterone-sulfate and negative pelvic ultrasound for adnexal masses. An androgen-secreting ovarian tumour was suspected and all of them were submitted to bilateral oophorectomy. Histology confirmed the diagnosis of Leydig cell tumours in 3 patients and mature teratoma in 1. A successful response to surgery, which includes a decline in serum androgen levels and signs of hyperandrogenism, was observed in our patients. This case series demonstrates that androgen-secreting ovarian neoplasms may not be detectable by imaging studies, but should be considered in the differential diagnosis of all postmenopausal women with signs of hyperandrogenism.

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  • Contributors All authors have substantial contributed for the conception and the design of this manuscript. AP has collected all the data, performed the required analysis and drafted the article. AAF, LC and APT performed a critical revision of the article. All authors approved the final version to be published.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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