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CASE REPORT
Acute febrile neutrophilic dermatosis associated with JAK-2 positive myeloproliferative disorder
  1. Dean Smyth1,
  2. Jey Selwyn2
  1. 1Forth Valley Royal Hospital, Larbert, UK
  2. 2Department of Medicine, NHS Forth Valley & University of Edinburgh, Larbert, UK
  1. Correspondence to Dr Jey Selwyn, jselwyn{at}nhs.net

Summary

We present a case of a 77-year-old man with a history of myeloproliferative disorder. He was admitted with a 2-week history of erythaema, swelling and significant pain of the right forearm following a mechanical fall at home, which had caused a skin laceration. During his admission, he developed ongoing intermittent fever and persistently elevated C reactive protein, and total white cell count. Initially, he was treated with antibiotics for suspected cellulitis. However, symptoms continued to progress, making a suitable management plan challenging. Wound swabs, blood cultures and viral PCR did not confirm infection. A punch biopsy of a skin lesion on the forearm was performed. The histology demonstrated a dense infiltrate of neutrophils and neutrophilic debris in keeping with acute febrile neutrophilic dermatosis (Sweet's syndrome). He was treated with oral steroids and after that he had a complete resolution of symptoms. However, he required a period of rehabilitation before returning home.

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