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Insulinoma with focal hepatic lesions: malignant insulinoma?
  1. Hichem Jerraya1,
  2. Yossra Zidi-Mouaffek2,
  3. Safi Dokmak3,
  4. Chadli Dziri4
  1. 1Faculty of Medicine, Department of Surgery, Tunis El Manar University, Tunis, Tunisia
  2. 2Department of Pathology, Charles Nicolle Hospital, Faculty of Medicine of Tunis, Tunis, Tunisia
  3. 3Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Paris, Texas, USA
  4. 4Department “B” of General Surgery, Charles Nicolle Hospital, Faculty of Medicine of Tunis, Tunis, Tunisia
  1. Correspondence to Professor Hichem Jerraya, jerrayahichem{at}


Insulinoma is a rare tumour that is malignant in only 10% of cases. We report a case of insulinoma in a 59-year-old woman, associated with focal liver lesions, which raised the suspicion of malignancy of a pancreatic tumour. Enucleation of the insulinoma was performed with wedge resection of one hepatic nodule. Pathological examination indicated that the pancreatic tumour was compatible with insulinoma whereas the hepatic lesion was related to focal nodular hyperplasia. This clinical case highlights the need for histopathological proof of malignancy before selecting therapeutic strategies for insulinomas.

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