Article Text

PDF
CASE REPORT
Hypothyroid heart: myxoedema as a cause of reversible dilated cardiomyopathy
  1. Nidhi Madan1,
  2. Nidhish Tiwari2,
  3. Morris Stampfer3,
  4. Ulrich Schubart4
  1. 1Department of Internal Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA
  2. 2Department of Cardiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA
  3. 3Department of Cardiology, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA
  4. 4Department of Endocrinology, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA
  1. Correspondence to Dr Nidhi Madan, nidhi0912{at}gmail.com

Summary

Hypothyroidism may cause several cardiac manifestations including conduction abnormalities, pericardial effusion, decreased myocardial contractility and accelerated coronary atherosclerosis. Although cardiac output is reduced in hypothyroidism, frank heart failure (HF) is relatively rare because of the low peripheral oxygen demand. Several mechanisms have been postulated in hypothyroid-induced HF, including genomic as well as non-genomic actions of thyroid hormone. Dilated cardiomyopathy (DCM) of other aetiologies is usually progressive, and is associated with significant morbidity and mortality. We report a case of DCM associated with severe hypothyroidism with marked improvement on restoration of euthyroid state. Our case is unique in that the patient had no known risk factors for cardiac disease and experienced marked improvement despite being on minimal doses of HF medications, illustrating the relationship between hypothyroidism and development of left ventricular dysfunction, and its reversible nature with restoration of euthyroid status.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.