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Multicystic dedifferentiated retroperitoneal liposarcoma: tumour cyst fluid analysis and implications for management
  1. Mitri Khoury1,
  2. Geok Choo Sim2,
  3. Michiko Harao3,
  4. Laszlo Radvanyi2,4,
  5. Behrang Amini5,
  6. Robert S Benjamin6,
  7. Peter W T Pisters7,
  8. Raphael E Pollock8,
  9. William W Tseng1,9
  1. 1Department of Surgery, Section of Surgical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA
  2. 2Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL
  3. 3Department of Breast Surgical Oncology, Tochigi Cancer Center, Utsunomiya, Japan
  4. 4Lion Biotechnologies, Woodland Hills, CA
  5. 5Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX
  6. 6Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
  7. 7University Health Care System, Toronto, Canada
  8. 8Division of Surgical Oncology, The James Cancer Center, Ohio State University, Columbus, OH
  9. 9Sarcoma Program, Hoag Family Cancer Institute and Hoag Memorial Hospital Presbyterian, Newport Beach, CA
  1. Correspondence to Dr William W Tseng, William.tseng{at}


Liposarcomas are soft tissue sarcomas of adipocyte origin. We describe a case of a dedifferentiated retroperitoneal liposarcoma with an unusual presentation on recurrence as a large, multicystic tumour. The patient was a 72-year-old woman who had undergone multiple treatments including two prior resections. For her most recent locoregional disease recurrence, the patient was offered surgical debulking for symptom palliation. At this operation, performed after two cycles of chemotherapy, the tumour cyst fluid was analysed and found to have a predominance of immune cells with no identifiable malignant cells. This case and the results of our tumour cyst fluid analysis raise several interesting considerations for the management of this unique situation in a rare disease.

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