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PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement
  1. Doen Ming Ong1,
  2. Katherine D Cummins1,
  3. Alan Pham2,
  4. George Grigoriadis3,4
  1. 1Department of Pathology (Haematology) and Clinical Haematology, Alfred Health, Melbourne, Victoria, Australia
  2. 2Department of Anatomical Pathology, Alfred Health, Melbourne, Victoria, Australia
  3. 3Alfred Pathology Service, Alfred Health, Melbourne, Victoria, Australia
  4. 4Department of Haematology, Monash Health, Clayton, Victoria, Australia
  1. Correspondence to Dr Doen Ming Ong, D.Ong2{at}


A 55-year-old man with a history of well controlled HIV infection was admitted with acute renal impairment, peripheral oedema, constitutional symptoms, deranged liver function and hypercalcaemia. Core biopsies of a retroperitoneal mass demonstrated anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL) with unusual Paired box 5 (PAX5) positivity. The same malignant cells were identifiable on urine cytology. Staging investigations revealed extensive nodal and extranodal disease including ALK negative ALCL involving the kidney and prostate, which has not previously been reported in the published literature.

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