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A 48-year-old man presented with a 24 h history of neck pain, vomiting, vertigo and impaired gait. On examination, he was found to have left gaze provoked nystagmus and left arm and leg dysmetria with mild weakness, symptoms attributable to cerebellar dysfunction. He underwent an unenhanced CT of the brain, which demonstrated possible thrombus in the basilar artery (figure 1). Aspirin 300 mg once daily was started. The following day, his left-sided symptoms deteriorated and he became dysarthric. He underwent MR of the brain including angiography, which demonstrated a filling defect in the basilar artery consistent with thrombus (figure 2), however, there was no haemorrhagic foci. He was started on intravenous heparin. Within a few days his symptoms resolved and he was discharged on clopidogrel.
Basilar artery thrombosis presents in a heterogeneous manner and carries a mortality of 80–90% if not promptly treated.1 In one case series, BAT presented acutely in one-third of patients studied, whereas it followed a progressive course over several weeks in the remainder. The most commonly presenting symptoms and signs included vertigo (54% of patients), hemiparesis (50%), bulbar/pseudobulbar signs (74%), oculomotor signs (45%) and headache (41%).2 It may arise as the result of artery-to-artery or cardioembolism, dissection with anterograde propagation of embolus/occlusion of the true lumen, or in-situ thrombosis. Accurate diagnosis of BAT relies on MR or CT angiography, as hyperdense basilar artery on unenhanced CT does not carry sufficient sensitivity or specificity.
Patients with basilar artery thrombosis may present acutely or with progressive/fluctuating posterior circulation symptoms and signs.
Basilar artery thrombosis is associated with significant morbidity and mortality.
Contrast enhanced imaging of the cervicocranial arteries using magnetic resonance or CT is required for the investigation of this condition.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.
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