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An 81-year-old man was investigated for weight loss, fever, deranged liver enzymes and elevated inflammatory markers. CT imaging revealed a lobulated well-defined anterior mediastinal mass (1.7×2.8×3.2 cm) and a further small (1.43×0.59×1.9 cm) subpleural nodule in the left posterior thorax. The possibility of mediastinal neoplasm was raised, with biopsy of the anterior mediastinal mass contemplated.
There was a history of blunt abdominal trauma 30 years prior, requiring surgical repair of a ruptured left hemidiaphragm, splenectomy and left nephrectomy. Considering this, a heat denatured red blood cell (RBC) study was performed. Tc-99m labelled autologous RBCs were warmed in a hot water bath to crenate but not lyse the cells, and were reinjected prior to SPECT-CT imaging. As the spleen functions to entrap and remove damaged RBCs, the heat-denatured RBC study is a very sensitive and specific method of identifying splenic tissue.1
The study demonstrated intense localisation of the labelled RBCs within the anterior mediastinal mass, with several less intense foci of uptake subpleurally in the left hemithorax and left upper quadrant of the abdomen (figure 1). These findings are characteristic of splenosis, with a prominent anterior mediastinal rest of splenic tissue. Biopsy of the anterior mediastinal mass was averted. Low grade ascending cholangitis secondary to choledocholithiasis was thought to account for symptoms. Follow-up chest X-ray demonstrated normal mediastinal contours (figure 2).
This is the first known report of anterior mediastinal splenosis following splenic rupture after abdominal trauma.
Diagnosis of thoracic splenosis can be made using denatured radiolabelled red blood cell (RBC) scans. The viable but crenated RBCs are rapidly cleared from the circulation by splenic tissue, making the test highly sensitive and specific in identifying splenic tissue.
Fusion SPECT-CT imaging allows for accurate anatomic localisation of lesions in nuclear medicine studies.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.