Article Text

Download PDFPDF
CASE REPORT
Fluoxymesterone-induced gynaecomastia in a patient with childhood aplastic anaemia
  1. Tom Edward Ngo Lo1,
  2. Zillien C Andal2,
  3. Frances Lina Lantion-Ang3
  1. 1Department of Medicine—Endocrinology, University of the Philippines—Philippine General Hospital, Manila, Philippines
  2. 2Department of Medicine—Hematology-Oncology, University of the Philippines—Philippine General Hospital, Manila, Philippines
  3. 3Section of Endocrinology, Diabetes and Metabolism Department of Medicine, University of the Philippines—Philippine General Hospital, Manila, Philippines
  1. Correspondence to Dr Tom Edward Ngo Lo, tomedwardlo{at}yahoo.com

Summary

Gynaecomastia is a benign condition characterised by enlargement of the male breast. Drug-induced gynaecomastia merits deep consideration as it may account for as many as 25% of all cases of gynaecomastia in adults. Although the mechanism is not fully clear, some mechanisms include oestrogen-like activities, stimulation of testicular production of oestrogens, inhibition of testosterone synthesis or blockade of androgen action. Anabolic steroids, in particular when used during the pubertal stage, may cause significant irreversible gynaecomastia. We report a case of 28-year-old Filipino man with persistent gynaecomastia from fluoxymesterone used for aplastic anaemia during his prepubertal stage. Hormonal work ups for gynaecomastia all turned out normal, thus isolating the drug as the cause. The patient was unable to undergo breast reconstruction surgery due to haematological contraindications, but eventually referred to psychiatry for counselling. This case will highlight the paradoxical effect of androgenic steroid used during childhood on male breast proliferation during puberty.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.