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Description
A 54-year-old man presented for evaluation of suspected metastatic lung cancer. He had been treated with multiple courses of antibiotics over the previous year for waxing-and-waning flu-like symptoms. A positron emission tomography CT scan performed 5 months previously showed a hypermetabolic 1.9 cm right middle lobe nodule with associated right hilar, right paratracheal and subcarinal lymphadenopathy (figure 1). A percutaneous biopsy of the right middle lobe nodule was non-diagnostic. Subsequently, the patient developed a large right pleural effusion and was referred to obtain tissue for diagnosis.
Thoracentesis was performed with drainage of 1050 mL of slightly red fluid. The fluid was exudative, and cytological evaluation was negative for malignancy. Gram stain and culture for bacterial, fungal and acid-fast organisms were unremarkable. Medical pleuroscopy was performed (video 1) and demonstrated thickening and erythema of the parietal pleura with multiple nodules studding the posterolateral pleura and diaphragm (figure 2). Biopsies taken from this area showed Coccidioides spp in a background of necrotising granulomatous inflammation (figure 3). The patient began treatment with fluconazole, which will be continued for at least 6 months.
Coccidioides spp are two fungal organisms (C immitis and C posadasii) endemic to deserts in the southwest USA, Mexico and Central America. Infection may occur following inhalation of airborne arthroconidia. Pulmonary coccidioidomycosis can present with a variety of radiological findings that mimic lung cancer. Pleural effusions occur in as many as 10% of patients.1 The diagnosis is occasionally made by thoracentesis, but often pleural biopsy is necessary.2
Learning points
Pulmonary coccidioidomycosis can present with a variety of radiological findings that mimic lung cancer, including parenchymal nodules and infiltrates, hilar and mediastinal lymphadenopathy, and pleural effusions.
Although the diagnosis of pleural coccidioidomycosis is occasionally made by pleura fluid analysis, biopsy of the parietal pleural is often necessary.
Footnotes
Contributors TMS and CAJ performed medical pleuroscopy and participated in patient management and follow-up. TMS and CAJ were involved in the preparation of the manuscript.
Competing interests None.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.