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Acute renal failure and type B lactic acidosis as first manifestation of extranodal T-cell lymphoblastic lymphoma
  1. Seongseok Yun1,
  2. Courtney N Walker1,
  3. Nicole D Vincelette2,
  4. Faiz Anwer1
  1. 1Department of Internal Medicine, University of Arizona Medical Center, Tucson, Arizona, USA
  2. 2College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Seongseok Yun, namaska97{at}


We describe a rare case of a 19-year-old male patient with a history of epilepsy and developmental delay who presented with acute renal failure (ARF) and lactic acidosis (LA) as the first manifestation of T-cell lymphoblastic lymphoma. Renal ultrasound and CT of the abdomen showed renal parenchymal infiltration, and renal biopsy demonstrated T-cell lymphoblastic lymphoma. LA, ARF and electrolyte abnormalities were refractory to the initial treatment of bicarbonate infusion and hydration. However, these abnormalities rapidly normalised after the initiation of chemotherapy, suggesting that the LA and ARF were secondary to lymphomatous renal infiltration.

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