Summary

A 51-year-old Caucasian man with a history of colon carcinoma, status post right hemicolectomy, now with elevated carcinoembryonic antigen underwent positron emission tomography (PET)/CT for evaluation of tumour recurrence. An incidental focal esophageal uptake was noted on PET/CT, without associated mass. Subsequent endoscopy revealed Barrett's esophagus. The second patient, a 63- year-old Caucasian man, underwent a PET/CT to characterise a 12 mm lung nodule. The PET/CT had linear diffuse uptake within the esophagus. Endoscopy and biopsy findings were consistent with reflux esophagitis. This case report discusses management of incidental esophageal uptake on fludeoxyglucose PET/CT.