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Tumour response following high-dose intratumoural application of Viscum album on a patient with adenoid cystic carcinoma
  1. Paul Georg Werthmann1,
  2. Dieter Helling2,
  3. Peter Heusser3,
  4. Gunver Sophia Kienle1
  1. 1Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Freiburg, Germany
  2. 2Medical Practice for General Medicine, Koblenz, Germany
  3. 3Faculty of Health, Chair of Theory of Medicine, Integrative and Anthroposophic Medicine, Institute of Integrative Medicine, University of Witten/Herdecke, Herdecke, Germany
  1. Correspondence to Paul Georg Werthmann, paul.werthmann{at}


Adenoid cystic carcinoma (ACC) is a rare type of cancer that typically originates in the salivary glands. Surgical removal can lead to functional loss and psychological distress. Viscum album extract (VAE) is a herbal remedy with dose-dependent cytotoxic, apoptogenic and immunological effects. In some case reports, tumour regression has been observed following high-dose local applications of VAE. An active 88-year-old man with fast-growing ACC of the hard palate refused surgical removal and received high-dose intratumoural injections of VAE (alone) over a 10-month period. The tumour decreased in size, softened and loosened from its surroundings. A biopsy during the course showed inflammation. The patient remained well and without functional limitations during the therapy and follow-up period (5 months). VAE produced no reported side effects. This aged patient exemplifies a satisfying course of ACC under VAE resulting in good quality of life and partial tumour regression.

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